Primary Sjogren's Syndrome Presenting with Rapidly Progressive Cognitive Impairment.
10.4078/jrd.2013.20.5.336
- Author:
Hee Won CHUNG
1
;
Jong Jin YOO
;
Byoong Yong CHOI
;
Hyun Jung CHO
;
Eun Ha KANG
;
Yeong Wook SONG
;
Yun Jong LEE
Author Information
1. Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Sjogren's syndrome;
Cognitive impairment;
Central nervous system
- MeSH:
Central Nervous System;
Cyclophosphamide;
Depression;
Dysarthria;
Female;
Follow-Up Studies;
Gait;
Humans;
Inflammation;
Memory;
Middle Aged;
Neurologic Manifestations;
Peripheral Nervous System Diseases;
Recurrence;
Sjogren's Syndrome*
- From:Journal of Rheumatic Diseases
2013;20(5):336-341
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Primary Sjogren's syndrome (pSS) is characterized by chronic inflammation and dysfunction in exocrine organs; however, it also has protean clinical features, including neuropsychiatric symptoms. A major neurological manifestation is peripheral neuropathy and involvement of the central nervous system is uncommonly described in pSS. A 52-year-old female was admitted because of depression, dysarthria, gait abnormality, and memory disturbance, which had developed over two months, and was diagnosed as pSS. She was treated successfully with high-dose glucocorticoid and cyclophosphamide pulse therapy without recurrence during the follow-up period of two years. Herein, we describe the first Korean case of pSS presenting with rapidly progressive cognitive impairment along with a review of the literature.
