Progress in the application of antimicrobial peptides in ocular surface infectious diseases
10.3760/cma.j.cn115989-20220210-00047
- VernacularTitle:抗菌肽在眼表感染性疾病中的应用进展
- Author:
Sanhua XU
1
;
Chonggang PEI
;
Yi SHAO
Author Information
1. 南昌大学第一附属医院眼科，南昌 330006
- Keywords:
Antimicrobial peptides;
Cornea;
Infections;
Ocular surface
- From:
Chinese Journal of Experimental Ophthalmology
2024;42(4):393-396
- CountryChina
- Language:Chinese
-
Abstract:
Due to their prolonged exposure to the external environment, eyes are susceptible to various infectious diseases of the ocular surface.In recent years, the resistance of pathogens to antimicrobial agents has led to poor treatment outcomes and significant deterioration in patients' vision and quality of life.Nowadays, ocular surface infectious diseases have become a global public health concern, necessitating the search for a safe and effective treatment.Antimicrobial peptides (AMPs), which act as antibiotic analogues, exhibit broad-spectrum antibacterial activity and are effective against a range of microbial infections, including bacteria, viruses, fungi, and parasites.AMPs play a crucial role in combating ocular surface infections.This review discusses the structure and function of AMPs, the mechanism of action of AMPs in ocular surface infections, the role of endogenous AMPs in fighting various ocular surface pathogens, the impact of exogenously induced AMPs on ocular surface infections, and recent research advances in AMPs.
