Application of corneal neutrotization in the treatment of neurotrophic keratopathy
10.3760/cma.j.cn115989-20210825-00476
- VernacularTitle:角膜神经移植在神经营养性角膜病治疗中的应用
- Author:
Sanhua XU
1
;
Jieli WU
;
Yi SHAO
Author Information
1. 南昌大学第一附属医院眼科，南昌 330006
- Keywords:
Nerve regeneration;
Neurotrophic keratopathy;
Corneal neurotization;
Neurointegration;
Corneal sensation;
Herpetic keratopathy
- From:
Chinese Journal of Experimental Ophthalmology
2024;42(3):297-300
- CountryChina
- Language:Chinese
-
Abstract:
Neurotrophic keratopathy (NK) is a degenerative disease in which damage to the corneal nerves leads to corneal hypoesthesia and even blindness.Traditional NK treatments aim at supporting corneal healing and preventing progression of corneal damage.In recent years, corneal neurotization has made some progress in NK.Compared with traditional treatment, it can not only solve the problem of corneal nerve defect, and avoid the subsequent keratopathy, but also significantly restore corneal sensitivity, corneal epithelium and vision.Corneal neurotization surgery methods are mainly divided into direct corneal neurotization (DCN) and inderect corneal neurotization (ICN).At present, this surgical method has gradually been used clinically, and has achieved satisfactory effects on unilateral NK caused by herpes virus and neuroma, as well as bilateral NK.However, it is little known about the surgical treatment of NK caused by dry eye, diabetes, and chronic glaucoma.In the future, multi-center prospective randomized studies can be conducted to further improve the treatment of NK with other causes.This article introduces this new surgical technique from three aspects, the specific surgical procedures of corneal neurotization, the selection of surgical methods, and the timing of the operation.
