Effect and significance of secretogranin Ⅲ in diabetic retinal neovascularization
10.3760/cma.j.cn115989-20201012-00688
- VernacularTitle:分泌粒蛋白Ⅲ在糖尿病性视网膜病变新生血管形成中的作用及意义
- Author:
Manqiao WANG
1
;
Xiaorong LI
Author Information
1. 天津医科大学眼科医院 天津医科大学眼视光学院 天津医科大学眼科研究所 国家眼耳鼻喉疾病医学研究中心天津市分中心 天津市视网膜功能与疾病重点实验室，天津 300384
- Keywords:
Secretogranin Ⅲ;
Diabetic retinopathy;
Angiogenesis;
Angiogenic factor;
Vascular endothelial growth factor
- From:
Chinese Journal of Experimental Ophthalmology
2024;42(1):93-96
- CountryChina
- Language:Chinese
-
Abstract:
Secretogranin Ⅲ (SCG3) is a kind of secretory granule widely distributed in tissues and cells with endocrine functions in the human body.As a member of the granin family, it is generally considered to be involved in endocrine and neuroendocrine regulatory activities, and also as a highly disease-selective angiogenic factor that reduces vascular leakage and neovascularization in animal models of diabetic retinopathy and retinopathy of prematurity.In addition, SCG3 also co-expresses with inflammatory factors, anti-brain-derived neurotrophic factors in nerve cells.This article reviewed the current understanding of SCG3 as a secretory granular protein and its granulocyte family, analyzed the distribution of SCG3 in vivo, discussed its role in angiogenesis, and considered the correlation between SCG3 and neovascularization.It focused on the possible role and significance of SCG3 in diabetic retinopathy, especially in relation to microangiopathy, inflammatory factors and retinal neurodegeneration.By comparing the differences between SCG3 and vascular endothelial growth factor (VEGF) in the binding of signaling pathways and related receptors, the effects and advantages of anti-SCG3 drugs in the treatment of DR were prospected.
