Mechanism of curcumin in the treatment of diabetic retinopathy based on network pharmacology and molecular docking
10.3760/cma.j.cn115989-20220314-00105
- VernacularTitle:基于网络药理学和分子对接探究姜黄素治疗糖尿病视网膜病变的药效机制
- Author:
Yuanyuan DU
1
;
Yiyun WANG
;
Rong ZHAO
;
Ji ZHANG
;
Xiaoyan JI
;
Jiayu LU
;
Fangfang JI
;
Hui LOU
;
Ziyuan JIANG
;
Jiang HUANG
Author Information
1. 苏州大学附属第二医院眼科，苏州 215004
- Keywords:
Curcumin;
Diabetic retinopathy;
Network pharmacology;
Genes
- From:
Chinese Journal of Experimental Ophthalmology
2023;41(12):1152-1159
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the mechanism of curcumin in the treatment of diabetic retinopathy (DR) by network pharmacology and molecular docking.Methods:The compounds targets of curcumin were predicted by SEA and SwissTargetPrediction databases, and the DR target genes were obtained by CTD database.The different genes were mapped and matched by Venny database to screen their intersections.The intersecting genes were submitted to GeneMANIA database to construct a protein-protein interaction network.WebGestalt database was used to conduct enrichment analysis and AutoDock Vina was used to perform molecular docking of the core targets.Results:A total of 52 targets of curcumin, 1 599 targets of DR and 48 intersecting targets were detected.The core targets were serine/threonine-protein kinase 1 (AKT1), tumor necrosis factor-α (TNF-α), epidermal growth factor receptor (EGFR), signal transduction and activator of transcription 3 (STAT3) and heat shock protein 90 alpha family class A member 1 (HSP90AA1). Enrichment analysis suggested that these targets were mainly associated with signaling pathways, including the EGFR tyrosine kinase inhibitor resistance signaling pathway, hypoxia-inducible factor-1 (HIF-1) signaling pathway, interleukin (IL)-17 signaling pathway and advanced glycosylation end product-the receptor of advanced glycosylation end product (AGE-RAGE) signaling pathway.Conclusions:Curcumin may play an important role in the treatment of DR by regulating multiple signaling pathways to inhibit the inflammatory response and combat oxidative stress.
