Research progress on the role of cell aging in dry age-related macular degen-eration
10.13389/j.cnki.rao.2024.0063
- VernacularTitle:细胞衰老在干性年龄相关性黄斑变性中的作用研究进展
- Author:
Mengxia CAI
1
;
Tingting WEI
;
Lingpeng ZHU
;
Yong YAO
Author Information
1. 214023 江苏省无锡市,南京医科大学附属无锡人民医院眼科,南京医科大学无锡医学中心
- Keywords:
age-related macular degeneration;
cell aging;
retinal pigment epithelial cells;
microglia;
choroidal vascu-lar endothelial cells;
mitochondria;
lysosome;
inflammation
- From:
Recent Advances in Ophthalmology
2024;44(4):324-328
- CountryChina
- Language:Chinese
-
Abstract:
Dry age-related macular degeneration(AMD)is a degenerative disease affecting the macular region of the retina,and aging changes in retinal and choroidal tissues are an important factor in AMD pathogenesis.Cell aging is an irre-versible state of cell cycle arrest triggered by certain physiological processes or stressful injury,affecting a variety of physi-ological and pathological processes.An increasing number of studies have shown that cell aging plays an essential role in the occurrence and development of AMD.This paper reviews the mechanisms of cell aging and its relationship with dry AMD,aiming to provide new ideas for the treatment of dry AMD.
