Research progress in the endogenous regulatory factors of corneal lym-phangiogenesis and its related ocular surface diseases
10.13389/j.cnki.rao.2024.0047
- VernacularTitle:角膜淋巴管生成的内源性调控因素及新生淋巴管相关眼表疾病研究进展
- Author:
Ziran ZHANG
1
;
Keran LI
Author Information
1. 211166 江苏省南京市,南京医科大学
- Keywords:
cornea;
corneal lymphangiogenesis;
endogenous regulatory factors;
ocular surface diseases
- From:
Recent Advances in Ophthalmology
2024;44(3):239-243
- CountryChina
- Language:Chinese
-
Abstract:
Blood and lymphatic vessels are absent from the normal cornea.Pathological stimulation such as corneal in-fection,chemical burns and transplantation rejection can disrupt the balance between pro-and anti-lymphangiogenesis fac-tors,causing lymphatic vessels to extend from the corneal limbus to the central cornea.Corneal lymphangiogenesis is closely related to various regulatory factors and cellular signaling pathways.Further study and elucidation of the mechanism of corneal lymphangiogenesis will open up new directions for treating corneal transplantation rejection,inflammatory disea-ses,dry eyes and tumor metastasis.This review concludes the endogenous regulatory factors of corneal lymphangiogenesis and therapeutic strategies for its related ocular surface diseases.
