Research on the macular microcirculation status and visual function changes of normal tension glaucoma patients
10.13389/j.cnki.rao.2024.0039
- VernacularTitle:正常眼压性青光眼患者黄斑区微循环状态与视功能改变的关系研究
- Author:
Caimei FAN
1
;
Miaomiao ZANG
;
Lijun WANG
;
Cheng YI
;
Luyao ZENG
;
Tianshuo WU
;
Hanlin LI
Author Information
1. 330006 江西省南昌市,南昌大学第一附属医院眼科
- Keywords:
normal tension glaucoma;
optical coherence tomography angiography;
microperimeter MP-3;
vessel den-sity;
retinal sensitivity;
fixation rate
- From:
Recent Advances in Ophthalmology
2024;44(3):197-202
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes in macular microcirculation status and visual function in patients with normal tension glaucoma(NTG)using the optical coherence tomography angiography(OCTA)and microperimeter MP-3 and analyze the correlation between the two.Methods In this cross-sectional observational study,17 NTG patients(30 eyes)were collected as the NTG group and then divided into mild,moderate and severe NTG subgroups according to the severity of the disease.During the same period,13 healthy subjects(23 eyes)with the same age and gender distribution were selected as the control group.OCTA was used to obtain linear density(LD)and perfusion density(PD)of superficial retinal vessels in the macular area.The microperimeter MP-3 was used to measure retinal sensitivity(RS)within 10° and fixation rate at 2° and 4° of the macular area.The OCTA parameters and microperimeter MP-3 parameters were compared among all groups,and the correlation between OCTA parameters and microperimeter MP-3 parameters in NTG patients was analyzed.Results There were no significant differences in LD and PD between the control group and the mild NTG sub-group in the central and nasal sides of the macula;the LD and PD in the remaining regions and overall average LD and PD showed a gradual downward trend in the control group and the mild,moderate and severe NTG subgroups.Compared with the control group,the RS of the mild NTG subgroup was lower in the inferior and temporal regions of the macular area.The RS of each region and overall average RS in the macular area decreased with the aggravation of the NTG.In the NTG group,LD and PD were significantly positively correlated with RS in each region and overall average RS in the macular area(all P＜0.05).In the NTG group,LD and PD were positively correlated with P2 in some regions of the macular area.Con-clusion Compared with the control group,the macular microcirculation status and visual function of NTG patients signif-icantly decreased with the progression of the disease;there is a significant correlation between macular LD and RS in NTG patients.
