Causality between body mass index and central retinal artery occlusion:a Mendelian randomized study
10.13389/j.cnki.rao.2024.0038
- VernacularTitle:体重指数与视网膜中央动脉阻塞之间的因果关系:一项孟德尔随机研究
- Author:
Zhao LIU
1
,
2
;
Li ZHOU
;
Qian XIE
;
Shanjun CAI
Author Information
1. 563003 贵州省遵义市,遵义医科大学附属医院眼科贵州省眼科医院国家眼病临床研究中心贵州省分中心贵州省眼疾病特色重点实验室
2. 563003 贵州省遵义市,遵义医科大学第一临床学院临床医学系
- Keywords:
body mass index;
central retinal artery occlusion;
Mendelian randomization
- From:
Recent Advances in Ophthalmology
2024;44(3):193-196
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the causal relationship between obesity and central retinal artery occlusion(CRAO)based on body mass index(BMI),which is commonly used to measure obesity,and Mendelian randomization(MR)method.Methods Two-sample MR analysis was performed using summary statistics from genome-wide associa-tion studies.Exposed genetic tools were divided into the men group(n=60 586,SNP=2 736 876,European men)and women group(n=171 977,SNP=2 494 613,European women);CRAO was selected as the outcome.The instrumental variable for BMI came from the Integrative Epidemiology Unit(IEU)publicly available data;the outcome CRAO data came from the FinnGen database.Inverse variance weighting(IVW)and weighted median(WM)were used to analyze the poten-tial relationship between BMI and CRAO.Results IVW showed that the increased BMI level significantly increased the risk of CRAO in men[OR=4.57,95％CI:1.32-15.82,P=0.016]and the risk of CRAO in women[OR=3.48,95％CI:1.40-8.63,P=0.007].Meanwhile,the WM and MR-Egger analysis results supported the above conclusions.In addition,there was no heterogeneity or pleiotropy in the results of this study.Conclusion The increase in BMI is positively corre-lated with the occurrence of CRAO.This study provides an effective CRAO prevention strategy for asymptomatic patients with elevated BMI levels.
