Research progress on the parvalbumin-positive inhibitory interneurons and visual developmental plasticity
10.13389/j.cnki.rao.2024.0029
- VernacularTitle:小清蛋白阳性抑制性中间神经元与视觉发育可塑性的研究进展
- Author:
Shiqiao YANG
1
;
Rui HAO
;
Wei ZHANG
Author Information
1. 300020 天津市,天津市眼科医院 南开大学附属眼科医院 天津医科大学眼科临床学院 天津市眼科研究所 天津市眼科学与视觉科学重点实验室
- Keywords:
parvalbumin;
inhibitory interneurons;
visual cortex;
plasticity;
critical period
- From:
Recent Advances in Ophthalmology
2024;44(2):149-154
- CountryChina
- Language:Chinese
-
Abstract:
The complex function of the brain depends on the interaction of its intrinsic neurons and neural network systems,in which glutamatergic projection neurons and GABAergic inhibitory interneurons play an important role.There is a critical period in the postnatal development of the visual system when it is susceptible to the external environment,which may affect visual plasticity.Changes in the visual environment can lead to adaptive adjustment in neural connections and synaptic structures among visual cortexes,and the perineural network in the extracellular matrix has been proven to play an essential role in this process.The parvalbumin-positive inhibitory interneurons(PV+INs)contained in the perineural net-works are also involved in regulating plasticity during the critical period of visual development.PV+INs are a kind of inter-neurons that express the parvalbumin found in various parts of the brain.Recent studies have demonstrated that specific modulation of these neurons not only reveals some potential therapeutic mechanisms for disorders such as amblyopia,de-pression and autism but also provides a more precise treatment for these diseases.In this paper,various regulatory factors of PV+INs from their origin to the end of the critical period of visual development and their involvement in visual develop-mental plasticity were reviewed,with the aim of providing some guidance for basic research on visual cortical plasticity.
