A Meta-analysis on the effects of different concentrations of atropine on myo-pia in Chinese children
10.13389/j.cnki.rao.2024.0026
- VernacularTitle:不同浓度阿托品对中国儿童近视控制效果的Meta分析
- Author:
Yang LI
1
;
Xiuxia LI
;
Xianni FENG
;
Limei ZHANG
;
Kangle GUO
Author Information
1. 735000 甘肃省酒泉市,酒泉市人民医院
- Keywords:
atropine;
Chinese children;
myopia control;
Meta-analysis
- From:
Recent Advances in Ophthalmology
2024;44(2):133-138
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the control effects of different concentrations of atropine on myopia in Chinese children.Methods PubMed,Embase,The Cochrane Library,Web of Science,CBM,WanFang Data,VIP and CNKI databases were retrieved to collect the studies on children's myopia control by atropine from the establishment of the database to April 2023.After the literature screening,data extraction and bias risk valuation were carried out by 2 research-ers,a Meta-analysis was performed via RevMan 5.4 software.Results A total of 32 studies were included,comparing the effects of 7 different concentrations of atropine and placebo.The Meta-analysis showed that compared with placebo,0.1 g·L-1 atropine had a significant impact on the change of spherical equivalent[MD=0.39,95％CI(0.26,0.52),P＜0.05],and significantly suppressed the axial length increment[MD=-0.18,95％CI(-0.24,-0.12),P＜0.05].Among other concentrations,0.2g·L-1,0.5g·L-1 and 10 g·L-1 atropine had sound effects on myopia control.Conclusion Exist-ing evidence shows that compared to placebo,atropine at concentrations of0.1 g·L-1,0.2 g·L-1,0.5 g·L-1and 10 g·L-1 has better effects on controlling the spherical equivalent and axial length of children with myopia.Among them,at-ropine at the concentration of 0.1 g·L1 may have the best effect.
