Research progress of the action of protein aggregation in cataract develop-ment
10.13389/j.cnki.rao.2024.0015
- VernacularTitle:蛋白质聚集在白内障发病中的作用研究进展
- Author:
Zhaoxing GUO
1
;
Xiuhua WAN
Author Information
1. 100005 北京市,首都医科大学附属北京同仁医院,北京同仁眼科中心,眼科学与视觉科学北京市重点实验室
- Keywords:
phakinin;
cataract;
gene mutation;
covalent modification;
protein interaction
- From:
Recent Advances in Ophthalmology
2024;44(1):76-79
- CountryChina
- Language:Chinese
-
Abstract:
Protein aggregation plays an essential role in the development of cataracts.In recent years,gene sequencing and other molecular biological techniques have been widely used in the study of protein aggregation,whose intrinsic mecha-nisms have been gradually elucidated.Gene mutations,isomerization and covalent modifications,compound and ionic in-teractions,and protein interactions are all causes of protein aggregation.This article focuses on the above four causes to review the research progress on the effect of protein aggregation in the development of cataracts,so as to provide informa-tion and reference for subsequent studies.
