Role of inflammation in diabetic retinopathy:pathogenesis and treatment strategies
10.13389/j.cnki.rao.2024.0001
- VernacularTitle:炎症在糖尿病视网膜病变中的作用:发病机制及治疗策略
- Author:
Jingfa ZHANG
1
Author Information
1. 200080 上海市,上海交通大学医学院附属第一人民医院眼科
- Keywords:
diabetic retinopathy;
inflammation;
inflammatory factors;
inflammatory cells;
microglia
- From:
Recent Advances in Ophthalmology
2024;44(1):1-12
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy(DR)is considered to be a chronic medium-and low-grade inflammatory disease(mi-croinflammation).Inflammation runs through the entire process of DR,manifesting as an increase in ocular and systemic inflammation biomarkers.In the eyes of DR patients,there is an increase in pro-inflammatory mediators,such as interleu-kin(IL)-1 β,IL-6 and tumor necrosis factor-α,as well as activated and increased number of inflammatory cells,such as ac-tivated microglia,Müller cells in the retina,and infiltration of mononuclear macrophage.In addition,immunocytes are also involved in the pathogenesis of DR,such as the involvement of circulating T cells in leukostasis.These indicate that chronic inflammation is an inducing factor of DR,with multiple inflammation-related factors participating and influencing each other,leading to the destruction of the blood-retinal barrier and neuronal injury and exacerbating the development of DR.There-fore,personalized anti-inflammatory therapy is of great significance in the treatment of DR.
