Advances in the role of microglia polarization in the pathogenesis of retinal degenerative diseases
10.13389/j.cnki.rao.2023.0198
- VernacularTitle:小胶质细胞极化在视网膜退行性疾病发病过程中的作用研究进展
- Author:
Haiyan ZHANG
1
;
Ya MO
Author Information
1. 610071 四川省成都市,成都中医药大学
- Keywords:
retinal degenerative diseases;
microglia polarization;
M1 phenotype microglia;
M2 phenotype microglia
- From:
Recent Advances in Ophthalmology
2023;43(12):997-1000
- CountryChina
- Language:Chinese
-
Abstract:
Microglia is involved in the occurrence and development of retinal degenerative diseases,thus its activation is a marker for retinal degenerative diseases.Microglia can be activated by different external stimulating factors and polar-ized into two phenotypes with different functional states and surface markers.The classical activation pathway produces M1 phenotype microglia,which mainly exerts pro-inflammatory and neurotoxic effects;the selective activation pathway pro-duces M2 phenotype microglia,which mainly exerts anti-inflammatory and neuroprotective effects.Precise modulation of microglia polarization is a promising approach for treating retinal degenerative diseases.This paper reviews the role of mi-croglia polarization in the pathogenesis of retinal degenerative diseases,aiming to pioneer new avenues and research ideas for treating retinal degenerative diseases.
