Research progress on the role of mitochondrial DNA in the pathogenesis of diabetic retinopathy
10.13389/j.cnki.rao.2023.0197
- VernacularTitle:线粒体DNA在糖尿病视网膜病变发病机制中的作用研究进展
- Author:
Xiaoyu HOU
1
;
Chuanhong JIE
;
Jianwei WANG
;
Ziqiang LIU
;
Yu DENG
;
Yuanyuan LI
;
Wenjing CAI
Author Information
1. 100040 北京市,中国中医科学院眼科医院
- Keywords:
diabetic retinopathy;
mitochondrial DNA;
DNA methylation;
oxidative stress;
gene mutation
- From:
Recent Advances in Ophthalmology
2023;43(12):992-996
- CountryChina
- Language:Chinese
-
Abstract:
In the early stage of diabetes retinopathy(DR),the change in the molecular level is often earlier than chan-ges in retinal microvessels.Under the chronic high-glucose environment,oxidative stress,epigenetic changes and other mechanisms cause retinal mitochondrial DNA(mtDNA)damage,affect the transcription process of mtDNA coding genes,and damage the electronic transport chain,leading to a vicious cycle of free radicals,which accelerates the apoptosis of retinal capillary pericytes and endothelial cells,leads to retinal microcirculation dysfunction,and cause DR.This paper will review the epigenetic changes,oxidative stress,damage to replication and repair system,gene mutation and other aspects,in order to elaborate on the research progress of retinal mtDNA damage in the pathogenesis of DR.
