Advances in the effect of inflammatory factors on immune mechanism of aplastic anemia

VernacularTitle:炎症因子对再生障碍性贫血免疫机制的影响研究进展
Author: Pingxin ZHANG ¹ ; Limin CHAI ; Guiyu FENG ; Dongyang LI ; Song SUN ; Wei LIU ; Yingkai ZHANG
Author Information

1. 北京中医药大学东直门医院重点实验室,北京 100700
Keywords: aplastic anemia; regulatory T cell; factor-related apoptosis/factor-related apoptosis ligand signaling pathway; microRNAs
From: Journal of Xinxiang Medical College 2024;41(3):298-301
CountryChina
Language:Chinese
Abstract: The pathogenesis of aplastic anemia(AA)is complex and associated with hematopoietic stem cell defect,abnormal bone marrow microenvironment,immune dysfunction,and somatic mutation,in which the immune mechanism plays an important role.This article reviews the pathogenesis of AA from the following aspects:regulatory T cell reduction,hematopoietic stem cell reduction caused by factor-related apoptosis/factor-related apoptosis ligand signaling pathway,aberrant target gene expression induced by inflammatory factor-stimulated microRNAs,and regulatory T cell dysfunction,so as to provide ideas and methods for clinical practice.