Regularity and mechanism of medicinal and edible herbs in the treatment of myelosuppression
10.7683/xxyxyxb.2024.03.005
- VernacularTitle:药食同源类中药治疗骨髓抑制的用药规律及潜在机制分析
- Author:
Yiqiao GAO
1
;
Yixin ZHANG
;
Yuye YANG
;
Zhaowei WEI
Author Information
1. 新乡医学院药学院药物分析学教研室,河南 新乡 453003
- Keywords:
medicinal and edible herbs;
myelosuppression;
regularity;
potential mechanisms
- From:
Journal of Xinxiang Medical College
2024;41(3):221-226,231
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the regularity and potential mechanisms of medicinal and edible herbs(MEHs)in the treatment of myelosuppression through the retrieval,summary,sorting and visual analysis of relevant literature.Methods Literature about MEHs treatment for myelosuppression was reviewed in document databases,such as Web of Science,CNKI,Wanfang Data Knowledge Service Platform,China Science and Technology Journal Database,and China Biology Medicine Disc.Multivariate statistical analysis was performed using the SPSS and CiteSpace software to explore the frequency,efficacy and correlation of MEHs,as well as the potential mechanisms of MEHs in treating myelosuppression.Results A total of 123 recipes involving 170 traditional Chinese medicines(including 38 MEHs)were screened out.Five pairs of MEHs core combinations in the treatment of myelosuppression were obtained by cluster analysis.Their main functions included benefiting qi and nourishing blood,invigo-rating spleen and dispelling dampness,replenishing qi and solidifying kidney.The potential mechanisms were associated with many related signal pathways,such as Janus kinase 2-signal transducer and activator of transcription 5 andβ-catenini.Conclusion MEHs such as radix astragali combined with angelica sinensis,poria cocos and codonopsis pilosula are mainly used clinically to treat myelosuppression induced by chemotherapy.They play their therapeutic effects by promoting proliferation and delaying senescence of hematopoietic stem cells.
