Research progress in oncolytic virus and immunotherapy for liver cancer
10.7683/xxyxyxb.2024.02.015
- VernacularTitle:溶瘤病毒及免疫疗法治疗肝癌研究进展
- Author:
Chenyang DU
1
;
Hongyan XU
;
Jie ZHANG
;
Chuan QIN
;
Junhe ZHANG
Author Information
1. 新乡医学院健康中原研究院,河南 新乡 453003
- Keywords:
liver cancer;
oncolytic virus;
targeted therapy;
immunotherapy
- From:
Journal of Xinxiang Medical College
2024;41(2):187-190
- CountryChina
- Language:Chinese
-
Abstract:
Liver cancer is one of the most common cancers,and its common surgical treatment methods include tran-scatheter arterial chemoembolization,radiofrequency ablation,and liver transplantation surgery.However,the treatment effect of these surgeries on patients with mid-to late-stage liver cancer is not ideal.In recent years,with the continuous development of tumor gene therapy and tumor immunology,tumor treatment methods have transitioned from traditional models to targeted onco-lytic virus therapy.With the advantages of fast replication,the oncolytic virus can kill tumor cells without damaging other normal cells and realize the targeted treatment of liver cancer through mechanisms such as activating the immune system and improving the tumor microenvironment.In addition,immunotherapy can reduce tumor recurrence and metastasis,thereby exerting therapeutic effects on liver cancer.This article reviews the research progress of oncolytic virus and immunotherapy for liver cancer,aiming to provide a reference for the clinical treatment of liver cancer.
