Research progress on therapeutic effect of exosomes from different sources on ischemic cerebrovas-cular disease

VernacularTitle:不同来源外泌体对缺血性脑血管病的治疗作用研究进展
Author: Tianchi GAO ^{1
,

2} ; Dandan NING ; Zheyi ZHOU
Author Information

1. 广西中医药大学,广西南宁 510120
2. 柳州市中医医院神经内科,广西柳州 545002
Keywords: exosomes; ischemic cerebrovascular disease; therapeutic effect
From: Journal of Xinxiang Medical College 2024;41(1):82-87
CountryChina
Language:Chinese
Abstract: Ischemic cerebrovascular disease(ICVD)refers to the degeneration,necrosis,or transient loss of function of local brain tissue due to blood supply disorders,and is one of the common neurological diseases.Exosomes are a subgroup of extracellular vesicles,characterized by good biocompatibility,low toxicity and immunogenicity,and strong designability.The components of exosomes include proteins,lipids,genetic materials,etc.They come from a wide range of sources and can be secreted by various cells under physiological or pathological conditions.The roles and related mechanisms of exosomes from different sources in the treatment of ICVD are different.This article reviews the therapeutic effects and related mechanisms of exesomes derived from mesenchymal stem cells,brain cells,blood,endothelial cells,and macrophages on ICVD,in order to provide reference for the clinical treatment of ICVD.