Research progress on pathogenesis and targeted therapy of ferroptosis mediated by nuclear factor E2-related factor 2 in diabetic cardiomyopathy
10.7683/xxyxyxb.2023.12.015
- VernacularTitle:核因子E2相关因子2介导的铁死亡在糖尿病心肌病中的发病机制及其靶向治疗研究进展
- Author:
Yuanhui GUO
1
,
2
,
3
;
Jiajia DUAN
;
Chuanxin LIU
;
Hongwei JIANG
Author Information
1. 河南科技大学临床医学院,河南 洛阳 471003
2. 河南科技大学第一附属医院内分泌代谢中心,河南 洛阳 471003
3. 河南省罕见病实验室,河南 洛阳 471003
- Keywords:
ferroptosis;
diabetic cardiomyopathy;
nuclear factor E2-related factor 2;
targeted therapy;
oxidative stress
- From:
Journal of Xinxiang Medical College
2023;40(12):1178-1183
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic cardiomyopathy is one of the leading causes of heart failure and death in diabetic patients.There is classic evidence of ferroptosis in the development of diabetic cardiomyopathy,which proves that ferroptosis is correlated with the diabetic cardiomyopathy.Oxidative stress caused by excessive production of reactive oxygen species and loss of antioxidant capacity is considered to be the main mechanism leading to diabetic cardiomyopathy.As one of the key regulatory factors of oxi-dative stress,nuclear factor E2-related factor 2(NRF2)and its target gene play an important role in the prevention and treat-ment of diabetic cardiomyopathy.This article summarizes the mechanism of ferroptosis and the pathogenesis of diabetes cardio-myopathy,and expounds the relationship between them,and focuses on the molecular mechanism of NRF2 in the development of diabetic cardiomyopathy and its targeted treatment effect.
