Epidural Morphine Block for Chronic Pain.
- Author:
Chang Rak CHOI
1
;
Young KIM
;
Jang Hoy HWANG
;
Myung Soo AHN
Author Information
1. Department of Neurosurgery, St. Paul's Hospital, Catholic Medical College, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Chronic pain;
Epidural morphine block
- MeSH:
Arachnoid;
Arachnoiditis;
Chronic Pain*;
Humans;
Injections, Epidural;
Morphine*;
Nociceptors;
Posterior Horn Cells;
Receptors, Opioid;
Spinal Cord;
Subarachnoid Space;
Substantia Gelatinosa
- From:Journal of Korean Neurosurgical Society
1983;12(3):369-374
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Epidural injection of 2-4mg morphine for 7-14 days were given to 18 patients with severe chronic pain. All cases except 2 arachnoiditis had considerable amelioration of pain, which commenced within 2-3min, reached a peak in 10-20min, and was effective for 6-72 hours. Using sensory evoked potentials(SEP) examination for pre-and post-morphine epidural infusion in 18 pain patients, we found the morphine inhibited the action of spinal pain receptor system. It is suggested that morphine reached the subarachnoid space and produced its effect by direct action on the specific opiate receptors in the substantia gelatinosa of the posterior horn cell of the spinal cord.
