Effects of pre-PCI application of ticagrelor on postoperative NF-κB signaling pathway,platelet ag-gregation and myocardial microcirculatory perfusion in patients with acute myocardial infarction and multivessel lesions
10.3969/j.issn.1008-0074.2024.01.12
- VernacularTitle:AMI多支病变患者PCI术前应用替格瑞洛对其术后NF-κB信号通路、血小板聚集及心肌微循环灌注的影响
- Author:
Lin REN
1
;
Hao CHEN
;
Jia-Yu ZHAO
;
Li-Xiang MA
Author Information
1. 秦皇岛市第一医院心血管内科,河北秦皇岛 660000
- Keywords:
Myocardial infarction;
Platelet aggregation;
Tegretol
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2024;33(1):55-60
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of preoperative ticagrelor application on postoperative NF-κB signa-ling pathway,platelet aggregation and myocardial microcirculatory perfusion in patients with acute myocardial in-farction(AMI)and multivessel lesions undergoing percutaneous coronary intervention(PCI).Methods:A total of 120 AMI patients with multivessel lesions treated in our hospital were selected,randomly and equally divided into clopidogrel group and ticagrelor group.Corresponding drugs were given in each group before and after PCI.NF-κB signaling pathway related indexes,platelet aggregation rate,myocardial microcirculatory indexes before and af-ter medication,and incidence of major adverse cardio-and cerebrovascular events(MACCE)were observed and compared between two groups.Results:On 7d after PCI,compared with clopidogrel group,there were significant reductions in corrected TIMI frame count(CTFC)of left anterior descending(LAD)[(23.83±2.69)vs.(20.48± 3.05)],left circumflex(LCX)[(20.93±2.82)vs.(18.35±2.37)]and right coronary artery(RCA)[(23.68± 3.15)vs.(21.13±2.79)]in ticagrelor group,P=0.001 all;compared with clopidogrel group after 30d treatment,there were significant reductions in platelet maximum aggregation rate,maximum depression amplitude of ST seg-ment,ST segment depression time,24h ischemia onset times,levels of Toll-like receptor 4(TLR4)protein,NF-κB protein,tumor necrosis factor(TNF)-a and interleukin(IL)-6 in ticagrelor group,P=0.001 all.There was no significant difference in incidence rate of MACE between two group within six months,P=0.186.Conclu-sion:Ticagrelor can improve myocardial microcirculation,inhibit platelet aggregation,and reduce inflammatory re-sponse in AMI patients with multivessel lesions,and the mechanism may be related to the inhibition of NF-κB sig-naling pathway activity by ticagrelor.
