Therapeutic effect of Jiangya Yishen granules combined amlodipine on elderly essential hypertension and its impact on serum levels of HbA1c and renalase protein
10.3969/j.issn.1008-0074.2024.01.11
- VernacularTitle:降压益肾颗粒联合氨氯地平治疗老年原发性高血压的疗效及对血清糖化血红蛋白及肾胺酶水平的影响
- Author:
Can LIU
1
;
Ya-Wei CAO
;
Shu-Xia ZHANG
Author Information
1. 衡水市第二人民医院老年病科,河北 衡水 053000
- Keywords:
Hypertension;
Jiangya Yishen granules;
Amlodipine;
Hemoglobin A,glycosylated
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2024;33(1):50-55
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the therapeutic effect of Jiangya Yishen granules(JYG)combined with amlodip-ine on elderly patients with essential hypertension(EH)and its impact on serum levels of glycosylated hemoglobin(HbA1c)and renalase protein.Methods:A total of 125 elderly EH patients treated in our hospital were selected.According to random number table,they were divided into amlodipine group(n=40),JYG group(n=40)and combined treatment group(n=45,received amlodipine combined with JYG).Each group received corresponding treatment for eight weeks.Therapeutic effect,antihypertensive effect,serum levels of renalase protein and HbA1c were compared among three groups before and after treatment.Results:Total effective rate of combined treatment group was significantly higher than those of amlodipine group and JYG group(88.9％vs.65.0％vs.70.0％),P＜0.05 or＜0.01;compared with amlodipine group and JYG group after treatment,there were significant improve-ments in blood pressure variability indexes(P＜0.05 or＜0.01),significant rise in renalase protein level[(1380.17 ±120.13)pg/ml vs.(1480.17±110.93)pg/ml vs.(1845.43±112.38)pg/ml],and significant reduction in HbA1c level[(5.92±0.35)％vs.(5.83±0.36)％vs.(5.31±0.35)％]in combined treatment group,P=0.001 all.Conclusion:Jiangya Yishen granules combined with amlodipine can strengthen antihypertensive effect,reduce HbA1c level and increase renalase protein level in elderly patients with essential hypertension,which can benefit the patients.
