Clinical study of sacubitril valsartan sodium combined with Wenxin granule in the treatment of hyper-tension complicated with paroxysmal atrial fibrillation
10.3969/j.issn.1008-0074.2024.01.09
- VernacularTitle:沙库巴曲缬沙坦钠联合稳心颗粒治疗高血压并发阵发性心房颤动的临床研究
- Author:
Yong HOU
1
;
Lian-Fa WANG
;
Hong-Tao LU
;
Zhen CHEN
;
Meng-Xun HUANG
;
Chen CHEN
;
Bang-Zhu ZHANG
;
Quan-Xiu TONG
;
Yun-Fei WANG
Author Information
1. 中国人民解放军联勤保障部队第九○一医院心内科,安徽 合肥 230032
- Keywords:
Hypertension;
Atrial fibrillation;
Sacubitril valsartan;
Wenxin granule
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2024;33(1):40-44
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore therapeutic effect of sacubitril valsartan sodium combined with Wenxin granule in the treatment of hypertension complicated with paroxysmal atrial fibrillation(AF)and its effect on cardiac electro-physiological structure.Methods:A total of 116 patients with hypertension and paroxysmal atrial fibrillation treated in our hospital from Oct 2021 to Nov 2022 were consecutively selected.According to random number table,they were divided into Wenxin granule group(received Wenxin granule treatment based on routine antihypertensive ther-apy)and combined treatment group(received sacubitril valsartan sodium combined Wenxin granule therapy based on routine antihypertensive therapy)with 58 cases in each group,and both groups were consecutively treated for six months.Clinical symptom score,AF burden,P wave duration,P wave dispersion,left atrial diameter(LAD),left ventricular end-diastolic diameter(LVEDd)and left ventricular ejection fraction(LVEF)were compared between two groups before and after treatment.Results:After treatment,compared with Wenxin granule group,there were significant reductions in clinical symptom score[(1.66±0.69)scores vs.(1.40±0.53)scores],AF burden[4.43(1.65)％vs.1.62(3.50)％],P wave duration[(112.17±6.46)ms vs.(109.29±8.59)ms],P wave dispersion[(32.47±8.11)ms vs.(29.02±7.49)ms]and LAD[(34.83±3.41)mm vs.(33.40±3.74)mm]in combined treatment group(P＜0.05 or＜0.01).There were no significant difference in LVEDd and LVEF between two groups,P＞0.05 both.Conclusion:Sacubitril valsartan sodium combined with Wenxin granule can significantly im-prove clinical symptoms and atrial fibrillation burden,reduce the susceptibility to atrial fibrillation,and inhibit atrial electrical remodeling and structural remodeling in patients with hypertension complicated with paroxysmal atrial fi-brillation.
