Analysis of AHNAK2 gene polymorphism in Xinjiang patients with coronary heart disease
10.3969/j.issn.1008-0074.2023.06.02
- VernacularTitle:新疆冠心病患者的AHNAK2基因多态性分析
- Author:
Ming-Yuan WANG
1
;
Xian WEI
;
Adi DILARE
;
Meng-Meng WANG
;
Ting-Ting WU
;
Xiang XIE
;
Bao-Zhu WANG
;
Yi-Tong MA
Author Information
1. 新疆医科大学第一附属医院心脏中心,新疆 乌鲁木齐 830054
- Keywords:
Coronary disease;
Polymorphism,single nucleotide;
Risk factors
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2023;32(6):555-559
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between the polymorphisms of AHNAK2 gene rs12882641,rs28583515 and rs2582497 loci and coronary heart disease(CHD)in the population of Xinjiang.Materials:This study used a case-control method,a total of 602 patients who were hospitalized and underwent coronary angiogra-phy(CAG)at ourheart center from Jan 2019 to Dec 2021 were selected.According toCAG results,the patients were divided into CHD group(n=301)and non-CHD group(n=301).The AHNAK2 gene rs12882641,rs28583515 and rs2582497 loci were genotyped using the improved multiple ligase detection reaction(iMLDR)technique,and the relationship between AHNAK2 gene polymorphisms and CHD was analyzed.Results:Compared with non-CHD group,there was significant rise in the distribution frequencies of AC+CC genotypes(52.8%vs.61.1%,P= 0.040)at rs2582497 locus of the AHNAK2 gene under the dominant model;there was significant reduction in distri-bution frequency of the CC genotype(65.8%vs.53.8%)at the rs28583515 locus of the AHNAK2 gene,and signif-icant rise in distribution frequencies of CT+TT(34.2%vs.46.2%)under the dominant model,TT under the re-cessive model(0.7%vs.3.0%)and CT under the additive model(33.6%vs.43.2%)in CHD group,P＜0.05 or＜0.01.After adjusting for confounding factors,logistic regression analysis indicated that the dominant model of the rs28583515 locus remained an independent risk factor for CHD(OR=1.509,P=0.036).Conclusion:The AH-NAK2 gene rs28583515 locus is closely related to the occurrence and development of CHD in the Xinjiang popula-tion.The dominant model of the AHNAK2 gene rs28583515 locus is an independent risk factor for CHD.
