Efficacy of melatonin therapy for neonatal hypoxic-ischemic encephalopathy: systematic review and meta-analysis
10.3760/cma.j.issn.2096-2932.2024.04.008
- VernacularTitle:褪黑素治疗新生儿缺氧缺血性脑病有效性的系统评价和Meta分析
- Author:
Chao ZHANG
1
;
Huaiqing YIN
;
Chongjuan YIN
;
Wenlong ZHANG
;
Yajing ZHONG
;
Rui SHI
Author Information
1. 山西医科大学第一临床医学院，山西医科大学第一医院儿科，太原 030001
- Keywords:
Hypoxic-ischemic encephalopathy;
Melatonin;
Neonate;
Meta-analysis;
Therapy
- From:Chinese Journal of Neonatology
2024;39(4):229-235
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically evaluate the clinical efficacy of melatonin for neonatal hypoxic-ischemic encephalopathy (HIE).Methods:From the inception of the databases to December 1, 2022, randomized controlled trials (RCTs) and cohort studies on the use of melatonin for HIE were searched in the following databases: PubMed, Web of Science, Cochrane library, Embase, Chinese Medical Journal Full-text Database, CNKI, Wanfang Database and VIP Database. Meta-analysis, literature risk assessment and sensitivity analysis were conducted using R4.2.2 software and RevMan5.4 software.Results:A total of 4 eligible RCTs were found, including 155 patients. Meta-analysis showed that melatonin could reduce the mortality rate ( RR=0.336, 95% CI0.157-0.718, P=0.005) and white blood cell count in HIE infants ( MD=-1.74, 95% CI -3.404--0.079, P=0.040). Sensitivity analysis showed that the Meta-analysis results were generally stable after excluding the studies one by one. Conclusions:Current evidence shows that melatonin can reduce mortality in HIE infants. However, the included studies have high risk of bias and small sample sizes. More high-quality studies are still needed.
