Analysis of clinical characteristic and risk factors for necrotizing enterocolitis in one of the premature twins
10.3760/cma.j.issn.2096-2932.2024.04.001
- VernacularTitle:早产双胎之一发生坏死性小肠结肠炎的临床特征及危险因素分析
- Author:
Jing LI
1
;
Yanshan CHEN
;
Mengyuan YANG
;
Falin XU
;
Huifang DONG
Author Information
1. 郑州大学第三附属医院新生儿科，郑州 450052
- Keywords:
Premature infants;
Necrotizing enterocolitis;
Twins;
Characteristic;
Risk factors
- From:Chinese Journal of Neonatology
2024;39(4):193-198
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the clinical characteristics and risk factors of necrotizing enterocolitis (NEC) in one of the premature twins.Methods:A retrospective study was conducted on twin premature infants who were admitted to the Department of Neonatology at the Third Affiliated Hospital of Zhengzhou University from January 2017 to December 2022 and only one got NEC. The twins were divided into NEC group and control group, the clinical data were collected and analyzed by SPSS 26.0 statistical software.Results:This study enrolled 109 pairs of premature twins, 109 cases in the NEC group, and 109 cases in the control group. Univariate analysis showed that birth weight, pre NEC white blood cell count were lower in NEC group than those in the control group, while the proportion of smaller than gestational age (SGA), donor of twin-to-twin transfusion syndrome, feeding intolerance, incomplete enteral feeding, start feeding time >48 h, red blood cell transfusion 72 h before NEC onset and the neutrophils ratio were higher in the NEC group than that of the control group, the difference was statistically significant ( P<0.05). Multivariate logistic analysis showed that low birth weight ( OR=1.558, 95% CI1.197-2.142), SGA ( OR=1.721, 95% CI 1.217-2.536), feeding intolerance ( OR=3.798, 95% CI 1.347-10.706), and incomplete enteral feeding ( OR=4.319, 95% CI 1.673-11.149) were independent risk factors for NEC ( P<0.05). Conclusions:Low birth weight, small for gestational age, feeding intolerance, and incomplete enteral feeding are independent risk factors for NEC in one of the premature twins.
