Non-protein-bound iron and oxidative stress status in cord blood of small for gestational age infants
10.3760/cma.j.issn.2096-2932.2023.11.007
- VernacularTitle:小于胎龄儿脐血非蛋白结合铁和氧化应激状况的研究
- Author:
Yuanlong LI
1
;
Jun LU
Author Information
1. 中南大学湘雅医学院附属海口医院儿科，海口 570208
- Keywords:
Oxidative stress;
Markers of oxidative stress;
Non-protein bound iron;
Small for gestational age
- From:Chinese Journal of Neonatology
2023;38(11):671-674
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the level of non-protein-bound iron (NPBI) and oxidative stress status in cord blood of small for gestational age (SGA) infants.Methods:From March 2021 to December 2021, late preterm and term infants born in department of obstetrics at our hospital with umbilical arterial bood (UAB) sampled were enrolled in this retrospective study. SGA infants were assigned into SGA group and appropriate for gestational age (AGA) group was matched in a 1∶1 ratio to SGA group selecting from all the AGA infants. The levels of NPBI, 8-isoprostagladin F2α (8-iso-PGF2α) and malondialdehyde (MDA) in UAB were compared between the two groups. The correlations of NPBI and other indicators were analyzed.Results:A total of 68 infants were enrolled, including 34 in SGA group and 34 in AGA group. SGA group had significantly higher levels of NPBI [3.9(2.6,5.1) nmol/ml vs. 0.8(0.2,1.4) nmol/ml], 8-iso-PGF2α[ (119.6±30.2) pg/ml vs. (66.5±22.7) pg/ml) ] and MDA [4.6(4.1, 5.1) nmol/ml vs. 3.4(2.9,3.8) nmol/ml] than AGA group ( P<0.05). The levels of 8-iso-PGF2α and MDA were positively correlated with NPBI in SGA group ( r=0.582, P=0.001; r=0.371, P=0.031). In AGA group, NPBI was positively correlated with MDA level ( r=0.492, P=0.003), but not with 8-iso-PGF2α ( r=0.032, P=0.859). Conclusions:Oxidative stress exists in SGA and NPBI may induce oxidative stress in SGA through lipid peroxidation.
