Risk factors of bronchopulmonary dysplasia in extremely preterm/extremely low birth weight infants
10.3760/cma.j.issn.2096-2932.2023.10.003
- VernacularTitle:超早产儿/超低出生体重儿支气管肺发育不良危险因素分析
- Author:
Yang LIU
1
;
Linping ZHONG
;
Shuqiang GAO
;
Yiyong FU
;
Xue ZHONG
;
Rong JU
;
Ying WU
Author Information
1. 电子科技大学医学院附属妇女儿童医院·成都市妇女儿童中心医院新生儿科，成都 611731
- Keywords:
Extremely preterm infant;
Extremely low birth weight infant;
Bronchopulmonary dysplasia;
Risk factors
- From:Chinese Journal of Neonatology
2023;38(10):587-592
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the risk factors of bronchopulmonary dysplasia (BPD) in extremely preterm/extremely low birth weight infants(EPT/ELBWIs).Methods:From June 2019 to March 2022, clinical data of EPT/ELBWIs with gestational age <28 weeks or birth weight <1 000 g admitted to NICU of our hospital were retrospectively analyzed. They were assigned into BPD group and non-BPD group. Multivariate logistic regression analysis was used to find the independent risk factors for BPD and receiver operating characteristic (ROC) curve was used to determine the cut-off value for BPD. The incidences of BPD of the two groups were compared and the correlation between independent risk factors and BPD severity was analyzed.Results:A total of 82 EPT/ELBWIs were enrolled, including 47 (57.3%) in BPD group and 35 (42.7%) in non-BPD group. The BPD group had longer duration of both invasive and non-invasive mechanical ventilation (MV) [24.0(8.0, 38.0)d vs. 6.0 (0.2, 11.6)d, (38.4±14.5)d vs. (32.4±10.9)d], lower birth weight [906 (800, 970)g vs. 980 (880, 1 050)g],higher incidences of ureaplasma urealyticum colonization (48.9% vs. 22.9%) and hemodynamically significant patent ductus arteriosus (hsPDA) (76.6% vs. 51.4%) than the non-BPD group(all P<0.05). Multivariate logistic regression analysis showed that the independent risk factor for BPD was the duration of invasive MV ( OR=1.003, 95% CI 1.001-1.005). The cut-off value of invasive MV duration for predicting BPD was 14.4 d. The duration of invasive MV was positively correlated with BPD severity ( r=0.604, P<0.001). Conclusions:BPD is more likely to occur in EPT/ELBWIs with longer duration of invasive MV.
