Mechanism of obesity in the occurrence and development of gastroesophageal reflux disease

VernacularTitle:肥胖在胃食管反流病发生发展中的作用机制
Author: Yusujiang TUSUNTUOHETI ¹ ; Maimaitiaili MAIMAITIMING ; Aikebaier AILI
Author Information

1. 新疆医科大学研究生学院，乌鲁木齐　830054
Keywords: Gastroesophageal reflux; Obesity; Mechanical effects; Biological effects; Waist circumference; Cytokines
From: Chinese Journal of Digestive Surgery 2024;23(1):147-152
CountryChina
Language:Chinese
Abstract: Obesity is one of the main risk factors for gastroesophageal reflux disease (GERD). With the development of social economy, the global obesity population shows a continuous growth trend, leading to an increase in the incidence rate of GERD. Obesity, especially the central obesity, is closely related to GERD. The increase of intra-abdominal pressure caused by obesity may lead to the destruction of "anti-reflux barrier" through a variety of mechanical mechanisms, and the various cytokines produced by visceral adipose tissue in obesity population may contribute to the occurr-ence and development of GERD through various biological effects. The authors explore the mechanism of obesity in the occurrence and development of GERD from both mechanical and biological effects, aiming to help clinical physicians improve their understanding of GERD.