Incidence of venous thromboembolism in esophageal cancer: a real-world study of 8 458 cases
10.3760/cma.j.cn115610-20231227-00281
- VernacularTitle:食管癌静脉血栓栓塞症发生情况的真实世界研究（附8 458例报告）
- Author:
Kunyi DU
1
;
Xin NIE
;
Kexun LI
;
Changding LI
;
Kun LIU
;
Zhiyu LI
;
Kunzhi LI
;
Simiao LU
;
Kunhan NI
;
Wenwu HE
;
Chenghao WANG
;
Jialong LI
;
Haojun LI
;
Qiang ZHOU
;
Kangning WANG
;
Guangyuan LIU
;
Wenguang XIAO
;
Qiang FANG
;
Qiuling SHI
;
Yongtao HAN
;
Lin PENG
;
Xuefeng LENG
Author Information
1. 四川省肿瘤临床医学研究中心 四川省肿瘤医院·研究所 四川省癌症防治中心 电子科技大学附属肿瘤医院胸外科，成都 610041
- Keywords:
Esophageal neoplasms;
Surgical procedures, operative;
Venous thrombo-embolism;
Deep venous thrombosis;
Pulmonary embolism;
Therapy
- From:
Chinese Journal of Digestive Surgery
2024;23(1):109-113
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the incidence of venous thromboembolism (VTE) in patients with esophageal cancer (EC).Methods:The retrospective cohort study was conducted. The clinicopathological data of 8 458 EC patients who were admitted to Sichuan Cancer Hospital from January 2017 to December 2021 were collected. There were 6 923 males and 1 535 females, aged (64±9)years. There were 3 187 patients undergoing surgical treatment, and 5 271 cases undergoing non-surgical treatment. Observation indicators: (1) incidence of VTE in EC patients; (2) treatment and outcomes of patients with VTE. Measurement data with normal distribution were represented as Mean± SD, and comparison between groups was analyzed using the t test. Measurement data with skewed distribution were represented as M(range), and comparison between groups was analyzed using the nonparameter rank sum test. Count data were expressed as absolute numbers or percentages, and comparison between groups was analyzed using the chi-square test or Fisher exact probability. Comparison of ordinal data was analyzed using the nonparameter rank sum test. Results:(1) Incidence of VTE in EC patients. Of 8 458 EC patients, 175 cases developed VTE, with an incidence rate of 2.069%(175/8 458). Among 175 VTE patients, there were 164 cases of deep venous thrombosis (DVT), 4 cases of pulmonary embolism (PE), 7 cases of DVT and PE. There were 59 surgical patients and 116 non-surgical patients. There was no significant difference in thrombus type between surgical and non-surgical EC patients with VTE ( χ2=1.95, P>0.05). Of 3 187 surgical patients, the incidence of VTE was 1.851%(59/3 187), including an incidence of 0.157%(5/3 187) of PE. PE accounted for 8.475%(5/59) of surgical patients with VTE. Of 5 271 non-surgical patients, the incidence of VTE was 2.201%(116/5 271), including an incidence of 0.114%(6/5 271) of PE. PE accounted for 5.172%(6/116) of non-surgical patients with VTE. There was no significant difference in the incidence of VTE or PE between surgical patients and non-surgical patients ( χ2=1.20, 0.05, P>0.05). (2) Treatment and outcomes of patients with VTE. Among 175 EC patients with VTE, 163 cases underwent drug treatment, and 12 cases did not receive treatment. Among 163 cases with drug therapy, 158 cases underwent anticoagulant therapy, 5 cases were treated with thrombolysis. All the 163 patients were improved and discharged from hospital. Conclusions:The incidence of VTE in patients with EC is relatively low, as 2.069%. There is no significant difference in the incidence of VTE or thrombus type between surgical EC patients and non-surgical EC patients.
