A new definition of fatty liver disease: from nonalcoholic fatty liver disease to metabolic asso-ciated fatty liver disease
10.3760/cma.j.cn115610-20230909-00080
- VernacularTitle:脂肪性肝病新定义：从非酒精性脂肪性肝病到代谢功能障碍相关脂肪性肝病
- Author:
Yongkang WANG
1
;
Shiyu WEI
;
Chang LIU
;
Yong WAN
Author Information
1. 西安交通大学第一附属医院肝胆外科，西安 710061
- Keywords:
Liver diseases;
Metabolic associated fatty liver disease;
Nonalcoholic fatty liver disease;
Metabolic disease;
Liver fibrosis;
Cardiovascular disease;
Chron
- From:
Chinese Journal of Digestive Surgery
2023;22(S1):117-121
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, there has been increasing evidence that nonalcoholic fatty liver disease (NAFLD) is a manifestation of a systemic metabolic disease in liver. However, limitations in the definition and diagnostic criteria of NAFLD could not fully and accurately describe the metabolic disorder. A consensus statement proposed renaming NAFLD to metabolic associated fatty liver disease (MAFLD). Compared with NAFLD, MAFLD links fatty liver disease with metabolic factors such as overweight or obesity and diabetes, and the diagnosis of the disease no longer excludes the presence of metabolic abnormalities in patients with alcohol consumption or other chronic liver diseases. The authors focus on definition changes of fatty liver disease, discuss the epidemiological changes from NAFLD to MAFLD and the relationship of MAFLD with liver fibrosis and extrahepatic diseases, and also the significance of MAFLD for public health.
