Clinical value of semi-ex vivo intestinal autotransplantation for patients with mesenteric root regional tumors accompanied by vascular invasion
10.3760/cma.j.cn115610-20230914-00095
- VernacularTitle:半离体自体小肠移植用于肠系膜根部区域肿瘤伴血管侵犯患者的临床价值
- Author:
Xinyu YOU
1
;
Beichuan PANG
;
Donghui CHENG
;
Bangyou ZUO
;
Jipeng JIANG
;
Jianjie HAO
;
Tao LIU
;
Yu ZHANG
Author Information
1. 四川省医学科学院·四川省人民医院 电子科技大学附属医院肝胆胰外科，成都 610072
- Keywords:
Intestinal autotransplantation;
Abdominal neoplasms;
Revascularization;
Treatment;
Surgery;
Efficacy
- From:
Chinese Journal of Digestive Surgery
2023;22(11):1361-1366
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical value of semi-ex vivo intestinal autotrans-plantation (IATx) for patients with mesenteric root regional tumors accompanied by vascular invasion.Methods:The retrospective and descriptive study was conducted. The clinicopathological data of 6 patients who underwent semi-ex vivo IATx in the Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital from September 2021 to December 2022 were collected. There were 4 males and 2 females, aged (47±21)years. Observation indicators: (1) surgical conditions; (2) postoperative conditions; (3) follow-up. Measurement data with normal distribution were represented by Mean± SD. Count data were represented by absolute numbers. Results:(1) Surgical conditions. All 6 patients completed semi-ex vivo IATx successfully. The operation time, warm ischemia time, cold ischemia time, volume of intraoperative blood transfusion were (10.2±2.1)hours, (2.3±1.6)minutes, (49.2±15.6)minutes, (707±263)mL. Of the 6 patients, 3 patients were intraoperatively perfused with cold UW solution, while the other 3 were not. (2) Postoperative conditions. Results of postoperative pathological examination of the 6 patients showed 4 cases of pancreatic ductal adenocarcinoma, 1 case of cholangiocarcinoma, and 1 case of mesenteric fibromatosis. All 6 cases had nega-tive surgical margins and the duration of postoperative hospital stay was (19±4)days. None of the patient had gastrointestinal bleeding or anastomotic leakage postoperatively, and the autotransplanted intestine functioned well. There was no perioperative death, and intravenous rehydration was not required after discharge. (3) Follow-up. All 6 patients were followed up for (12±5)months. Only 1 patient with mesenteric fibromatosis had recurrence in the 7th month postoperatively, while the remaining 5 patients showed no sign of recurrence or metastasis. There were 4 of 6 patients with chronic diarrhea. They were improved after oral loperamide, bifidobacterium and pancreatin capsules. All 6 patients survived.Conclusion:Semi-ex vivo IATx for the treatment of patients with mesenteric root regional tumors accompanied by vascular invasion is safe and feasible, which can achieve good short-term efficacy.
