Precision therapy strategies and trends based on molecular characteristics for gastric cancer
10.3760/cma.j.cn115610-20230916-00102
- VernacularTitle:以分子分型为基础的胃癌精准治疗策略及发展趋势
- Author:
Hui CAO
1
;
Wenyi ZHAO
;
Enhao ZHAO
Author Information
1. 上海交通大学医学院附属仁济医院胃肠外科，上海 200127
- Keywords:
Stomach neoplasms;
Molecular characteristics;
Targeted therapy;
Immuno-therapy;
Precision therapy
- From:
Chinese Journal of Digestive Surgery
2023;22(10):1160-1165
- CountryChina
- Language:Chinese
-
Abstract:
China has the number of cases and deaths of gastric cancer ranking first in the world every year. Gastric cancer is a heterogeneous disease with significant individual differences and poor prognosis. In recent years, with the development of multi-omics technology, by analyzing different molecular subtypes and underlying mechanisms of gastric cancer, more and more targets and molecular features related to gastric cancer have been identified, targeted or immunotherapeu-tic drugs based on these molecular features have been partially applied in the clinical treatment of gastric cancer. In this article, the authors summarize the latest research progress based on the molecular characteristics of gastric cancer, elaborate on the current status and prospects of precise therapy strategies for gastric cancer, in order to provide new theoretical basis for improving the comprehensive treatment efficacy and prognosis of gastric cancer.
