Research progress on the role and changes of natural killer cells in sepsis

VernacularTitle:脓毒症中自然杀伤细胞的作用及其变化的研究进展
Author: Zhihui PENG ¹ ; Haipeng YAN ; Zhenghui XIAO
Author Information

1. 南华大学儿科学院，长沙　410007
Keywords: Sepsis; Innate immunity; Nature killer cells; Activated receptors; Inhibitory receptor
From: Chinese Pediatric Emergency Medicine 2024;31(2):141-145
CountryChina
Language:Chinese
Abstract: Sepsis is the organ dysfunction caused by infection.It is one of the most common critical diseases in clinic.Its morbidity and mortality are increasing year by year，which has seriously threatened human health.Innate immunity is the first line of defense against pathogens.Nature killer（NK）cells are important cells involved in the regulation of innate immunity in sepsis，and can play an important role on the progression of sepsis by secreting cytokines，inducing apoptosis and mediating cytotoxic effects.It has been found that the changes of NK cells in the early stage of sepsis are related to the prognosis of the disease.Therefore，further study on the role of NK cells in sepsis can provide a new idea for the clinical diagnosis and treatment of sepsis，and contribute to the early identification of sepsis and the improvement of prognosis.This review summarized the role and changes of NK cell in sepsis.