Regulation effect of dopamine on sepsis-associated macrophage functions and the mechanisms involved

VernacularTitle:多巴胺对脓毒症中巨噬细胞功能的调控及机制研究
Author: Wenting SONG ¹ ; Yinfeng ZHANG ; Bailu DU ; Xi MO ; Qing CAO
Author Information

1. 上海交通大学附属儿童医学中心感染科　200127
Keywords: Dopamine; Sepsis; Macrophage; Inflammation; Regulatory
From: Chinese Pediatric Emergency Medicine 2024;31(1):52-56
CountryChina
Language:Chinese
Abstract: Sepsis is a life-threatening organ dysfunction caused by the host disordered response to infections.As one of the most important innate immune cells in the body，macrophages can maintain the immune homeostasis by recruiting other immune cells，clearing pathogens，presenting antigens，and play important regulatory roles in infectious diseases such as sepsis by releasing inflammatory factors.As a critical neurotransmitter，dopamine not only participates in the neurological processes such as learning and cognition，but also regulates the immune processes，including regulating the activation，proliferation and functional changes of immune cells such as neutrophils，lymphocytes，monocytes and macrophages.Current studies demonstrate that during the infection and inflammation process of sepsis，the phagocytosis，polarization，and release of inflammatory factors of macrophages are regulated by dopamine.This review summarized the recent research progress on the regulatory functions and the underlying mechanisms of dopamine on macrophages in sepsis.