Sepsis-induced thrombocytopenia-associated multiple organ failure

VernacularTitle:脓毒症诱导的血小板减少相关多器官衰竭
Author: Tiening ZHANG ¹ ; Chunfeng LIU ; Ni YANG
Author Information

1. 中国医科大学附属盛京医院儿童急诊与重症医学科，沈阳　110004
Keywords: Sepsis; Thrombocytopenia; Sepsis-induced thrombocytopenia-associated multiple organ failure
From: Chinese Pediatric Emergency Medicine 2024;31(1):24-27
CountryChina
Language:Chinese
Abstract: Sepsis-induced thrombocytopenia-associated multiple organ failure（TAMOF）is a severe subtype of sepsis-related organ dysfunctions，which has high mortality and poor prognosis.The main clinical characteristics are thrombocytopenia caused by infection and multiple organ dysfunction.However，the exact molecular mechanism of TAMOF remains unclear.The current studies have shown ADAMTS-13，which is a von Willebrand factor lyase，plays an important role during the disease.Plasma exchange could be a treatment method，but still need more large-scale randomized controlled trials to verify.In the future，von Willebrand factor and ADAMTS-13 could become the therapeutic targets for new drug development.