Progress on diagnosis and treatment of trauma induced coagulopathy in children
10.3760/cma.j.issn.1673-4912.2023.10.003
- VernacularTitle:儿童创伤性凝血病的诊疗进展
- Author:
Jiru LI
1
;
Xiaodong ZHU
Author Information
1. 上海交通大学附属新华医院儿急危重症医学科 200092
- Keywords:
Trauma;
Coagulopathy;
Pathophysiological mechanism;
Treatment
- From:
Chinese Pediatric Emergency Medicine
2023;30(10):731-735
- CountryChina
- Language:Chinese
-
Abstract:
Trauma is a major cause of death in children.Hypoperfusion, tissue cell injury, inappropriate thrombin generation, fibrinogen depletion and dysregulated fibrinolysis are the main pathophysiological mechanisms of trauma induced coagulopathy.The conventional coagulation tests and thromboelastography are helpful for the diagnosis of trauma induced coagulopathy, and thromboelastography can guide clinical transfusion therapy. "Optimized end-organ perfusion" and "adequate oxygen delivery" are resuscitation goals.Active and correct pre-hospital treatment, damage control resuscitation, justified transfusions and antifibrinolytic therapy are helpful to improve the prognosis of children with trauma induced coagulopathy.
