An Unusual Case with Membranous Lipodystrophy in a Hypertensive Patient with Transepidermal Elimination.
10.3349/ymj.2006.47.3.428
- Author:
Hana BAK
1
;
Jin Wook LEE
;
Hyung Jin AHN
;
Sang Min HWANG
;
Eung Ho CHOI
;
Seung Hun LEE
;
Sung Ku AHN
Author Information
1. Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea. ahnsk@wonju.yonsei.ac.kr
- Publication Type:Case Report
- Keywords:
Transepidermal elimination;
membranous lipodystrophy;
hypertension
- MeSH:
Skin Diseases/*pathology;
Lipodystrophy/*complications/*pathology;
Hypertension/*complications;
Humans;
Female;
Epidermis/*pathology;
Adult
- From:Yonsei Medical Journal
2006;47(3):428-431
- CountryRepublic of Korea
- Language:English
-
Abstract:
Membranous lipodystrophy represents a peculiar type of fat necrosis that is present in patients with various types of skin disease. It is characterized by the presence of microcysts and macrocysts and is lined by amorphous eosinophilic material with a crenelated arabesque appearance. These findings have been associated with lupus erythematosus, diabetes mellitus, erythema nodosum, trauma, etc. We report a case of a 43-year-old woman who had a red to purple asymptomatic indurated plaque, approximately seven cm in diameter and on the left arm. She was a chronic hepatitis B antigen carrier and had hypertension for four years. Histopathology of the biopsied lesion showed transepidermal elimination of altered collagen and elastic fibers, as well as membranous lipodystrophy changes. There were hypertensive vascular changes including lymphohistiocytic infiltration around the vascular wall, swelling of endothelial cells, increased thickness of the vascular walls, and narrowing of the lumen. We report a case showing transepidermal elimination with membranous lipodystrophy. We carefully suggest that the secondary phenomenon of transepidermal elimination was associated with membranous lipodystrophy and degenerate connective tissues.
