Causal association of micronutrients with osteonecrosis:evidence from a bidirectional Mendelian randomization trial
- VernacularTitle:微量营养素与骨坏死的因果关系:来自双向孟德尔随机试验的证据
- Author:
Wei LI
1
;
Jinlian CHAI
;
Haifeng JIA
;
Hanzheng LI
;
Tiefeng SUN
;
Xuezhen LIANG
Author Information
- Keywords: osteonecrosis; micronutrients; Mendelian randomization; causality; reverse causality; genome-wide association study; ferroptosis; instrumental variable
- From: Chinese Journal of Tissue Engineering Research 2024;33(33):5308-5314
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:Osteonecrosis is a common refractory disease in clinical practice,and observational studies have suggested that micronutrients may have a prognostic role in osteonecrosis.However,the specific causal association between micronutrients and osteonecrosis is not known. OBJECTIVE:To explore the causal association between micronutrients and osteonecrosis by Mendelian randomization using summary data from a large population-based genome-wide association study(GWAS)for clinical diagnosis and treatment. METHODS:The required exposure and outcome data(calcium,magnesium,iron,vitamin E,carotenoids,retinol&osteonecrosis)were extracted from the IEU OpenGWAS database,GWAS catalog database,and FinnGen database.Data were analyzed by bidirectional Mendelian randomization with inverse-variance weighted as the primary study method,and weighted median method,simple mode method,weighted mode method,and MR-Egger regression to complement the results.The reliability of the data was then verified through sensitivity analyses. RESULTS AND CONCLUSION:(1)The results found a positive correlation between serum iron concentration and osteonecrosis,while no correlation was found for other micronutrients.There was no reverse causality in all the data.(2)The results of sensitivity analysis showed a robust causality.(3)By Mendelian randomization method,this study provided evidence of causality between serum iron concentration and osteonecrosis,and understanding the causality of micronutrient elements on osteonecrosis can help in the clinical diagnosis and treatment of osteonecrosis,which is of great clinical significance.
