Myocardial Protective Effect of Histidine-Tryptophan-Ketoglutarate Solution and Cold Blood Cardioplegic Solution in Pediatric Cardiac Surgery.
10.12701/yujm.2006.23.1.19
- Author:
Tae Eun JUNG
1
;
Dong Hyup LEE
;
Sung Sae HAN
Author Information
1. Department of Thoracic and Cardiovascular Surgery, College of Medicine, Yeungnam University, Daegu, Korea. tejung@med.yu.ac.kr
- Publication Type:Original Article
- Keywords:
Cardioplegic solution;
Myocardial protection;
Congenital heart surgery
- MeSH:
Cardioplegic Solutions*;
Electrocardiography;
Heart Septal Defects, Atrial;
Heart Septal Defects, Ventricular;
Humans;
Incidence;
Thoracic Surgery*;
Troponin T
- From:Yeungnam University Journal of Medicine
2006;23(1):19-25
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: There is limited data on comparisons between the effect of histidine-tryptophan-ketoglutarate (HTK) solution and cold blood cardioplegic (CBC) solution in pediatric cardiac surgery. The purpose of this study was to compare the myocardial protective effect of HTK solution and CBC solution in patients undergoing pediatric cardiac surgery. MATERILAS AND METHODS: We selected 49 patients with ventricular septal defect and atrial septal defect. HTK solution was used in 21 patients and CBC solution was used in 28 patents. HTK solution was given as a single dose, whereas CBC solution was used in the usual multi-dose method. The incidence of EKG change and concentration of Troponin T and CK-MB were compared for the evaluation of myocardial damage. RESULTS: There were no significant differences in the incidence of ST, T segment change by EKG and serial cardiac enzyme levels between two groups. CONCLUSION: These results suggested that the myocardial protective effect of HTK solution was similar to CBC solution in simple pediatric cardiac surgery.
