Antibiotic-loaded bone cement enhances ability of tibial cortex transverse transport for treating infected wounds
- VernacularTitle:抗生素骨水泥增强胫骨横向骨搬运治疗感染创面的能力
- Author:
Junpeng LIU
1
;
Xingchen YAO
;
Hui ZHAO
;
Ziyu XU
;
Yue WU
;
Fuchun PEI
;
Lin ZHANG
;
Xinru DU
Author Information
- Keywords: tibial cortex transverse transport; antibiotic-loaded bone cement; diabetic foot ulcer; revascularization; infection control; ankle joint; tissue engineering research; diabetic complication
- From: Chinese Journal of Tissue Engineering Research 2024;28(29):4599-4604
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:Diabetic foot patients with wound infections constitute a large patient population,and there is currently no satisfactory treatment approach. OBJECTIVE:To investigate the clinical efficacy of a modified tibial cortex transverse transport combined with antibiotic-loaded bone cement for treating refractory diabetic foot ulcers. METHODS:A total of 46 diabetic foot ulcers patients,27 males and 19 females,with an average age of 64.37 years,were selected from Beijing Chaoyang Hospital,Capital Medical University and Beijing Chaoyang Integrative Medicine Rescue and First Aid Hospital from January 2020 to January 2023.All of them underwent the modified tibial cortex transverse transport combined with antibiotic-loaded bone cement treatment.Ankle-brachial index,WIFi(Wound/Ischemia/Foot infection)classification,pain visual analog scale score,and ulcer area were recorded before and 3 months after surgery. RESULTS AND CONCLUSION:(1)The mean ulcer healing time for the 46 patients was(58.07±24.82)days.At 3 months postoperatively,there were significant improvements in ankle-brachial index,pain visual analog scale score,ulcer area,and WIFi classification in 46 patients,as compared to the preoperative values,with statistically significant differences(P<0.05).Two patients experienced pin-tract infections,without infection or ulcer recurrence during the follow-up period.(2)These findings indicate that the modified tibial cortex transverse transport combined with antibiotic-loaded bone cement effectively alleviates patients'pain,improves lower limb circulation,controls infections,and promotes ulcer healing.
