Relationship between statin drugs and bone density:a drug target-mediated Mendelian randomization study
10.12307/2024.555
- VernacularTitle:他汀类药物与骨密度:一项药物靶向孟德尔随机化分析
- Author:
Weiwei MA
1
;
Yong XIONG
;
Honggu CHEN
;
Wenzhuo HUANG
;
Xin HUANG
;
Xiaohong ZHOU
Author Information
1. 湖北中医药大学,湖北省武汉市 430061
- Keywords:
statin drugs;
bone mineral density;
Mendelian randomization;
genome-wide association study;
causal relationship
- From:
Chinese Journal of Tissue Engineering Research
2024;28(27):4340-4345
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Observational studies have suggested that statin drugs may have a protective effect on bone density,making them a potential treatment option for osteoporosis. OBJECTIVE:To evaluate the causal relationship between drug target-mediated lipid phenotypes and bone mineral density(BMD)using Mendelian randomization methods. METHODS:We obtained single nucleotide polymorphismsrelated to statin drugs and BMD data from the IEU Open GWAS database.The primary analysis method was the inverse variance weighted method,and we also used weighted median,simple median,weighted mode,and MR-Egger regression.We usedβ values and 95%confidence intervals(CI)to assess the causal relationship between statin drugs and BMD.Additionally,we conducted sensitivity analyses to validate the results,assessed heterogeneity using Cochran's Q test,examined for horizontal pleiotropy using the MR-Egger intercept test,and performed leave-one-out analyses to determine if individual or multiplesingle nucleotide polymorphism influenced the results. RESULTS AND CONCLUSION:There was a significant association between the statin target of action,3-hydroxy-3-methyl glutaryl coenzyme A reductase-mediated low-density lipoprotein cholesterol,and heel bone BMD(β=-0.086,95%CI:-0.117 to-0.055,P=5.42×10-8)and whole-body BMD(β=-0.193,95%CI:-0.288 to-0.098,P=7.35×10-5).The findings of this study support the protective effect of statin drugs on BMD.These findings not only deepen our understanding of the relationship between cholesterol-related genes and bone health but also reveal potential therapeutic targets for improving BMD.
