Potential of shikonin and its derivatives in oral soft and hard tissue regeneration
10.12307/2024.446
- VernacularTitle:紫草素及其衍生物在口腔软硬组织再生中的潜力
- Author:
Zhihong BIAN
1
;
Yuntao ZHANG
;
Zeming LI
;
Yudong HOU
Author Information
1. 滨州医学院,山东省滨州市 256600
- Keywords:
shikonin;
oral disease;
periodontitis;
antibacterial;
osteogenesis;
osteoclast
- From:
Chinese Journal of Tissue Engineering Research
2024;28(17):2747-2752
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Shikonin contributes to the promotion of bone defect repair and the treatment of osteoporosis. OBJECTIVE:To summarize the application potential of shikonin and its derivatives in oral soft and hard tissue regeneration. METHODS:A literature review was conducted in databases such as PubMed,Web of Science,Wanfang,China National Knowledge Infrastructure(CNKI),and VIP,spanning articles from 2002 to 2023.The search terms were"shikonin,oral cavity,periodontitis,antibacterial,bone formation,osteoclast,osteoporosis,toxicology"in Chinese and English. RESULTS AND CONCLUSION:Shikonin and its derivatives possess anti-inflammatory effects,inhibit periodontal pathogens such as Porphyromonas gingivalis,promote periodontal wound healing,and regenerate alveolar bone tissue.Shikonin formulations can be used to treat oral diseases such as aphthous ulcers and oral candidiasis.These findings suggest a promising future for shikonin and its derivatives in treating periodontal diseases,preventing oral ailments,and promoting the regeneration of both soft and hard periodontal tissues.Further research is needed to explore how to combine shikonin with tissue engineering to achieve quicker healing of oral soft and hard tissues.
