Advantages and features of nanocomposite hydrogel in treatment of osteoarthritis
- VernacularTitle:纳米复合水凝胶在骨关节炎治疗中的优势与特征
- Author:
Linling TIAN
1
;
Hairui GUO
;
Xiaoming DU
;
Jie FENG
;
Xianzhe ZHANG
;
Wenbin ZHANG
;
Haoran SUN
;
Xiaobin ZHANG
;
Jingxia WANG
;
Yimei HU
;
Yi WANG
Author Information
- Keywords: osteoarthritis; cartilage repair; cartilage tissue engineering; nanocomposite hydrogel; biomaterial; biological scaffold; cartilage scaffold; review
- From: Chinese Journal of Tissue Engineering Research 2024;28(15):2410-2415
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:Nanocomposite hydrogel has great research prospects and application potential in the treatment of osteoarthritis. OBJECTIVE:To review the research progress of nanocomposite hydrogel in osteoarthritis and cartilage repair. METHODS:Databases such as CNKI and PubMed were searched.The English key words were"nanocomposite hydrogel,nanogel,osteoarthritis,cartage,physical encapsulation,electrostatic interaction,covalent crosslinking",and the Chinese key words were"nanocomposite hydrogel,nanogel,osteoarthritis,cartage,physical encapsulation,physical encapsulation,electrostatic effect,covalent cross-linking".After an initial screening of all articles based on inclusion and exclusion criteria,71 articles with high correlation were retained for review. RESULTS AND CONCLUSION:In cell or animal experiments,nanocomposite hydrogel has the effect of improving osteoarthritis.Nanocomposite hydrogel can promote cartilage repair,improve the internal environment of osteoarthritis,and achieve the therapeutic purpose of osteoarthritis by improving the mechanical environment between joints,carrying targeted drugs,and promoting the chondrogenesis of seed cells.At present,the research of nanocomposite hydrogel in osteoarthritis disease still has a huge space to play.It is expected to open up a new way for the clinical treatment of osteoarthritis by continuing to deepen the research of material preparation and actively carrying out cell and animal experiments.
