Mammalian target of rapamycin in relation to exercise,high fat/high salt diet,and aging
- VernacularTitle:哺乳动物雷帕霉素靶蛋白与运动、高脂肪/高盐饮食和衰老的关系
- Author:
Shijie WANG
1
;
Dengtai WEN
;
Jingfeng WANG
;
Yinghui GAO
Author Information
- Keywords: aging; mTor; muscle; heart; high-fat/salt diet; exercise
- From: Chinese Journal of Tissue Engineering Research 2024;28(4):574-580
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:Aging is an irreversible process that is characterized by genes,diet and environment.As a central regulator of growth and development,mammalian target of rapamycin(mTor)can regulate the negative effects caused by aging,exercise and poor diet,which are correlated with the activity of mTor and its complexes.However,the relationship between these factors,such as mTor and the effect of exercise on aging,is still unclear. OBJECTIVE:To study the relationship between exercise,high fat/high salt diet and mTor in aging,so as to have a more comprehensive understanding of the prevention and treatment mechanism of aging. METHODS:(1)Literature retrieval was conducted in the core database of Web of Science and CNKI,using the keywords of"mTor gene,exercise,high fat/high salt diet,aging,"thereby providing theoretical support for this review.(2)Comparative analysis provided a theoretical basis for this thesis by carefully reading the obtained effective literature and comparing the differences among various literatures.(3)Through the comparative analysis of similarities and differences between the included articles,we could define each index and their relationship,so as to clarify the ideas of this review. RESULTS AND CONCLUSION:mTor is closely related to aging.Through the literature analysis,we believe that two complexes of mTor,mTorC1 and mTorC2,play important roles in aging,exercise and skeletal muscle growth and development.In addition,mTor-mediated S6K1,Akt,FOXO,and 4E-BP1 signaling pathways are strongly associated with exercise,high-fat diet,high-salt diet,and skeletal muscle/heart aging.
