Cartilage targeting function in the drug delivery system by intra-articular injection for the treatment of osteoarthritis
10.12307/2023.879
- VernacularTitle:关节腔注射治疗骨关节炎药物载体系统中的软骨靶向功能
- Author:
Junyan CHEN
1
;
Qingqi MENG
;
Siming LI
Author Information
1. 贵州医科大学,贵州省贵阳市 550025
- Keywords:
cartilage targeting;
intra-articular injection;
osteoarthritis;
cartilage penetration;
drug carrier;
biomaterial
- From:
Chinese Journal of Tissue Engineering Research
2024;28(3):458-463
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Intra-articular injection played an important role in the treatment of osteoarthritis and has more options with the development of novel drug delivery systems.The cartilage targeting function is aimed at the adhesion or retention of drugs in the cartilage layer to form a drug bank to achieve slow release and precise drug delivery. OBJECTIVE:To review various cartilage targeting biomaterials and their characteristics in the treatment of osteoarthritis by articular injection. METHODS:Using the term"osteoarthritis,drug carrier,drug delivery,cartilage targeting,penetrate"as key words,relevant articles were searched in CNKI,WanFang and PubMed databases.According to inclusion and exclusion criteria,67 articles were finally selected for further review. RESULTS AND CONCLUSION:The research on cartilage-targeting biomaterials is mainly divided into two directions.One is the combination of electrostatic interaction,such as the combination of positively charged biomaterials and negatively charged polysaccharides in cartilage.This kind of scheme is operable and easy to modify,but limited by the shortcomings of electrostatic interaction itself,it performs badly in advanced osteoarthritis.Another one is the specific binding of various components in cartilage which is strong and reliable,and related biomaterials have excellent performance in advanced osteoarthritis,which is an important direction for future cartilage-targeted therapy.
