Application of metal ions in bone tissue engineering
- VernacularTitle:金属离子在骨组织工程中的应用
- Author:
Xueyu GAO
1
,
2
;
Wentao ZHANG
;
Tianze SUN
;
Jing ZHANG
;
Zhonghai LI
Author Information
- Keywords: metal ion; bone defect; bone repair; bone regeneration; osteogenic activity; biomaterial; bone tissue engineering
- From: Chinese Journal of Tissue Engineering Research 2024;28(3):439-444
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:Metal ions play an important role in the human body.With the progress of material synthesis and processing technology,a variety of metal ions that can be used in bone tissue engineering have been developed,such as magnesium(Mg2+),zinc(Zn2+),manganese(Mn2+),strontium(Sr2+),and copper(Cu2+). OBJECTIVE:To summarize the research progress and development direction of metal ions in bone tissue engineering. METHODS:The literature collected by CNKI,PubMed and WanFang databases from 2014 to 2022 was retrieved.The Chinese and English key words were"metal ions,bone tissue engineering,osteogenic activity,magnesium ions,zinc ions,manganese ions,strontium ions,copper ions,calcium ions,lithium ions,cobalt ions". RESULTS AND CONCLUSION:Different metal ions will be released to varying degrees after the materials are implanted into the body,which can change the tissue microenvironment,thus improving the ability of materials to form blood vessels and bones.Compared with growth factors,metal ions are easier to control the release rate,have lower cost,and can also improve the mechanical properties of implant materials.The application of metal ions in bone tissue engineering is full of prospects.Although some metal ions can already be used to treat bone defects,the mechanism of action of many metal ions in the human body is not completely clear,and the application effect is a lack of clinical experiment verification.Further exploration is needed before clinical application.
