Electrospun nanofiber scaffolds for soft and hard tissue regeneration
- VernacularTitle:软组织和硬组织再生过程中的电纺纳米纤维支架
- Author:
Xinyi WANG
1
;
Xianrui XIE
;
Yujie CHEN
;
Xiaoyu WANG
;
Xiaoqing XU
;
Yihong SHEN
;
Xiumei MO
Author Information
- Keywords: electrostatic spinning; nanofibre; electrospun nanofiber scaffold; tissue engineering; tissue regeneration; soft tissue regeneration; hard tissue regeneration; review
- From: Chinese Journal of Tissue Engineering Research 2024;28(3):426-432
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:Currently,electrospun nanofibers,which are biomimetic materials of natural extracellular matrix and contain a three-dimensional network of interconnected pores,have been successfully used as scaffolds for various tissue regeneration,but are still faced with the challenge of extending the biomaterials into three-dimensional structures to reproduce the physiological,chemical as well as mechanical properties of the tissue microenvironment. OBJECTIVE:To summarize the process and principles of electrostatic spinning and to explore the applications of the resulting electrospun nanofibers in tissue regeneration of skin,blood vessels,nerves,bone,cartilage and tendons/ligaments. METHODS:With"electrospinning,electrospun nanofibers,electrospun nanofiber scaffolds,tissue regeneration"as the Chinese and English search terms,Google Academic Database,PubMed,and CNKI were searched,and finally 88 articles were included for review. RESULTS AND CONCLUSION:(1)The electrospun nanofibers are a natural fibrous extracellular matrix mimetic material and contain a three-dimensional network of interconnected pores that have been successfully used as scaffolds for a variety of tissue regeneration applications.(2)Several papers have described the great potential of electrospun nanofiber scaffolds applied to the regeneration of skin,blood vessels,nerves,bones,cartilage and tendons/ligaments,providing a solid theoretical basis for its final application in clinical disease treatment,or for its transformation into practical products to enter the market.(3)However,the current research results are mostly based on cell experimental research results in vitro,and whether it can be finally applied to human body still needs clinical verification.(4)At present,many kinds of electrospun products for various clinical needs have been commercialized in and outside China,indicating that the research field of electrospun nanofiber scaffolds for soft and hard tissue regeneration has great research value and application potential.
