Understanding of molecular pathogenesis and genetic markers in colorectal cancer.
- Author:
Young Ho KIM
1
Author Information
1. Department of Gastroenterology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- Publication Type:Review
- Keywords:
Colorectal cancer;
Genetic instability;
Epigenetic change;
Biomarker
- MeSH:
Colorectal Neoplasms;
Epigenomics;
Genetic Markers;
Genomic Instability;
Microsatellite Instability;
Oncogenes;
Translocation, Genetic
- From:Korean Journal of Medicine
2010;79(2):113-118
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Colorectal cancers results from the progressive accumulation of genetic and epigenetic alterations that lead to cellular transformation and tumor progression. Genomic instability, including chromosomal translocations and microsatellite instability, plays a role in acquisition of enough mutations for malignant transformation. In addition, epigenetic silencing is an important mechanism in the evolution of a subgroup of colorectal cancers. These genetic and epigenetic changes causes activation of oncogene pathway (APC, KRAS) and inactivation of tumor-suppressor pathway (p53, TGF-beta). Recent advance in colorectal carcinogenensis leads to development of molecular markers for early detection and predictive and prognostic markers.
